British Shorthair Genetic Pack

Tests included in this pack (5)

• Feline blood group genetic determination (dominant and recessive alleles)
• Autoimmune lymphoproliferative syndrome (ALPS)
• PKD PCR (polycystic kidney disease)
• Feline congenital hypothyroidism (British Shorthair, Domestic Longhair, Domestic Medium Hair, Domestic Shorthair, Russian Blue)
• Feline hypertrophic cardiomyopathy HCM4

Each test includes the complete analysis and the detailed report. Click on the test to see its information sheet.

Diseases included in this pack

Feline blood group genetic determination (dominant and recessive alleles) (Autosomal, CMAH allelic series A > a^c > b. A dominant over b; a^c dominant over b and recessive to A. A/A, A/b, A/a^c = type A; b/b = type B; a^c/a^c and a^c/b = type AB. Group B queens have anti-A antibodies (neonatal isoerythrolysis).)

This test determines by DNA the alleles of the cat AB blood group system: the A allele (dominant) and the b allele (recessive), which define groups A, b/B and AB. The group determines compatibility in transfusions and, above all, the risk of neonatal isoerythrolysis: a group b queen with anti-A antibodies can destro…

Autoimmune Lymphoproliferative Syndrome (ALPS) (Autosomal recessive)

Feline autoimmune lymphoproliferative syndrome, described in the British Shorthair (FALPS), caused by a variant in the FASLG gene. It presents with lymphadenopathy, splenomegaly, anaemia and lymphocytosis of double-negative lymphocytes (CD4-/CD8-). The mention of other breeds (e.g. British Longhair) is not supported…

PKD PCR (polycystic kidney disease) (Autosomal dominant)

Hereditary kidney disease characterized by the formation of multiple bilateral renal cysts from an early age. The cysts grow progressively, destroy functional parenchyma and progress to chronic kidney failure in adulthood. It is one of the most prevalent and best-characterized feline genetic diseases. The feline for…

Feline Congenital Hypothyroidism (British Shorthair, Domestic Longhair, Domestic Medium Hair, Domestic Shorthair, Russian Blue) (Autosomal recessive. Affected cats are homozygous for the variant; heterozygotes are healthy carriers.)

Congenital hypothyroidism is a hereditary disease in which the thyroid gland does not produce sufficient thyroid hormones from birth, usually due to a defect in hormone synthesis (iodine organification) that presents with goitre. It affects metabolism and development: kittens grow poorly, are apathetic and constipat…

Feline Hypertrophic Cardiomyopathy HCM4 (Limited data / not applicable for A74T (polymorphism without association with disease). For the known causal variants of feline HCM the observed pattern is autosomal dominant with incomplete, age-dependent penetrance.)

Feline genetic test corresponding to the A74T variant of MYBPC3. Important: A74T is a polymorphism that has NOT been shown to be associated with the hypertrophic cardiomyopathy phenotype (Longeri et al. 2013), so it must not be interpreted as a cause of HCM nor used to rule it out. The best-characterized causal vari…

Frequently asked questions

What does this pack include?

It includes 5 hereditary disease tests: Feline blood group genetic determination (dominant and recessive alleles), Autoimmune Lymphoproliferative Syndrome (ALPS), PKD PCR (polycystic kidney disease), Feline Congenital Hypothyroidism (British Shorthair, Domestic Longhair, Domestic Medium Hair, Domestic Shorthair, Russian Blue)…. All are analysed in our laboratory.

What do the results mean?

The report shows the genotype and inheritance pattern of each variant. It is a breeding-decision tool: it guides which crosses to avoid, it does not guarantee the absence of disease.

How is the sample taken?

Buccal swab or 0.5–1 ml EDTA blood. The kit ships free to Spain, the EU and the UK.