English Setter Genetic Pack

Tests included in this pack (3)

• Cord1 PRA (crd4-PRA, RPGRIP1)
• crd4-PRA / PRA-MAP9
• Neuronal ceroid lipofuscinosis 8 (NCL8) of the English Setter

Each test includes the complete analysis and detailed report. Click on the test to see its details.

Diseases included in this pack

Cord1 PRA (crd4-PRA, RPGRIP1) (Autosomal recessive with incomplete penetrance.)

Molecular test for cone-rod dystrophy 1 (Cord1) progressive retinal atrophy, a hereditary retinal degeneration that initially affects the cones and later the rods and leads to progressive blindness. It affects the ocular system (photoreceptors) and forces the animal to adapt to gradual visual loss. The test reports…

crd4-PRA / PRA-MAP9 (Autosomal recessive for the RPGRIP1 variant (cord1/crd4); the MAP9 deletion acts as an oligogenic modifier with an accelerating effect. Incomplete penetrance.)

RPGRIP1-CRD retinal degeneration (historically cord1 and registered in OMIA as cone-rod dystrophy 4, crd4) is a progressive retinal atrophy with onset in the puppy caused by the 44 bp insertion in RPGRIP1. The ~22 kb deletion in MAP9 behaves as an oligogenic modifier: it accelerates and aggravates the degeneration o…

Neuronal ceroid lipofuscinosis 8 (NCL8) of the English Setter (Autosomal recessive)

Neuronal ceroid lipofuscinosis of the English Setter caused by a missense mutation in CLN8. It accumulates autofluorescent material in neurons and produces progressive neurodegeneration with onset from juvenile to young adult. It is inherited in an autosomal recessive manner.

Frequently asked questions

What does this pack include?

It includes 3 hereditary disease tests: Cord1 PRA (crd4-PRA, RPGRIP1), crd4-PRA / PRA-MAP9, Neuronal ceroid lipofuscinosis 8 (NCL8) of the English Setter. All are analysed in our laboratory.

What do the results mean?

The report shows the genotype and inheritance pattern of each variant. It is a breeding-decision tool: it guides which crosses to avoid, it does not guarantee the absence of disease.

How is the sample taken?

Buccal swab or 0.5–1 ml EDTA blood. The kit ships free to Spain, the EU and the UK.