Sphynx Genetic Pack

Tests included in this pack (4)

• Feline blood group genetic determination (dominant and recessive alleles)
• PKD PCR (polycystic kidney disease)
• Feline hypertrophic cardiomyopathy HCM4
• Congenital myasthenic syndrome (CMS) - Devon Rex and Sphynx

Each test includes the complete analysis and the detailed report. Click on the test to see its data sheet.

Diseases included in this pack

Feline blood group genetic determination (dominant and recessive alleles) (Autosomal, CMAH allelic series A > a^c > b. A dominant over b; a^c dominant over b and recessive to A. A/A, A/b, A/a^c = type A; b/b = type B; a^c/a^c and a^c/b = type AB. Group B queens have anti-A antibodies (neonatal isoerythrolysis).)

This test determines by DNA the alleles of the cat AB blood group system: the A allele (dominant) and the b allele (recessive), which define groups A, b/B and AB. The group determines compatibility in transfusions and, above all, the risk of neonatal isoerythrolysis: a group b queen with anti-A antibodies can destro…

PKD PCR (polycystic kidney disease) (Autosomal dominant)

Hereditary kidney disease characterized by the formation of multiple bilateral renal cysts from an early age. The cysts grow progressively, destroy functional parenchyma and progress to chronic kidney failure in adulthood. It is one of the most prevalent and best-characterized feline genetic diseases. The feline for…

Feline Hypertrophic Cardiomyopathy HCM4 (Limited data / not applicable for A74T (polymorphism without association with disease). For the known causal variants of feline HCM the observed pattern is autosomal dominant with incomplete, age-dependent penetrance.)

Feline genetic test corresponding to the A74T variant of MYBPC3. Important: A74T is a polymorphism that has NOT been shown to be associated with the hypertrophic cardiomyopathy phenotype (Longeri et al. 2013), so it must not be interpreted as a cause of HCM nor used to rule it out. The best-characterized causal vari…

Congenital Myasthenic Syndrome (CMS) - Devon Rex and Sphynx (Autosomal recessive (OMIA:000684-9685).)

Molecular test for congenital myasthenic syndrome (CMS) in the Devon Rex and Sphynx cat, a hereditary disease of the neuromuscular junction caused by a deficiency of collagen-associated acetylcholinesterase (COLQ). It produces generalised muscle weakness and exercise intolerance due to defective neuromuscular transm…

Frequently asked questions

What does this pack include?

It includes 4 hereditary disease tests: Feline blood group genetic determination (dominant and recessive alleles), PKD PCR (polycystic kidney disease), Feline Hypertrophic Cardiomyopathy HCM4, Congenital Myasthenic Syndrome (CMS) - Devon Rex and Sphynx. All are analysed in our laboratory.

What do the results mean?

The report shows the genotype and inheritance pattern of each variant. It is a breeding-decision tool: it guides which crosses to avoid, it does not guarantee the absence of disease.

How is the sample taken?

Buccal swab or 0.5–1 ml EDTA blood. The kit ships free to Spain, the EU and the UK.