Multi-disease panel for the Vizsla grouping four molecular tests: neonatal cortical cerebellar abiotrophy (NCCD), exfoliative cutaneous lupus erythematosus (ECLE), hair length I (long or short hair) and furnishing (wire-haired/dense coat). It combines neurological, dermatological/immunological conditions and coat markers.

Applicable breed: Vizsla. Reliable country-specific frequencies for the breeding population are not published systematically (limited data). ECLE is a well-recognised condition in the breed but with a complex genetic basis.

- Cerebellar ataxia of neonatal onset, tremor, hypermetria (NCCD)\n- Exfoliative skin lesions, scaling, erosions and erythema on the face, ears and trunk (ECLE)\n- Progressive paresis of the hindlimbs with proprioceptive ataxia (DM)\n- Short or long hair depending on genotype (hair length I, FGF5)\n- Wire-haired/dense vs. smooth hair (furnishing, RSPO2) - these are not a disease

The different conditions of the panel were characterised independently. Hair length I is linked to the FGF5 gene and furnishing to the RSPO2 gene, both classic in canine coat genetics. NCCD of the Vizsla is associated with SNX14 c.2653+1G>A (Fenn 2016), distinct from that of the Beagle (SPTBN2). ECLE is an autoimmune skin disease described in the breed, with a complex genetic basis.

- Genotype breeding animals before mating; the panel covers four conditions/markers in a single sample\n- For NCCD (recessive): do not cross two carriers - 25% risk of affected homozygotes; carrier x clear is safe for offspring intended for breeding if tested\n- For ECLE: as it is a complex inheritance, the molecular test (if the laboratory includes it) does not predict risk deterministically; assess the family clinical history\n- For hair length I and furnishing: they guide coat prediction; they do not imply disease, but they inform the buyer\n- After a confirmed clinical case, do not repeat the parental cross and communicate the status to the buyer

Verify the exact panel contracted. NCCD is suspected by cerebellar ataxia in puppies; the differential diagnosis includes other cerebellar abiotrophies and malformations. ECLE is diagnosed by skin biopsy (histopathology and immunofluorescence) and molecular test; the differential diagnosis includes other autoimmune and infectious dermatoses. Hair length I and furnishing do not predict disease.

1. Fenn J et al. 2016, SNX14 y nueva degeneración cortical cerebelosa en Vizsla (PMID 27566131)