Test Detail

Pack vizsla: Neonatal cortical cerebellar abiotrophy (NCCD), exfoliative cutaneous lupus erythematosus (ECLE), hair length I and furnishing

General · Dog

Multi-disease panel for the Vizsla grouping four molecular tests: neonatal cortical cerebellar abiotrophy (NCCD), exfoliative cutaneous lupus erythematosus (ECLE), hair length I (long or short hair) and furnishing (wire-haired/dense coat). It combines neurological, dermatological/immunological conditions and coat markers.
Inheritance patternMixed: NCCD - autosomal recessive. DM exon 2 - autosomal recessive. ECLE - complex inheritance. Hair length and furnishing - coat markers.
Gene / MutationFGF5 (hair length I); RSPO2 (furnishing); SNX14 c.2653+1G>A (NCCD of the Vizsla); ECLE - no single causal variant (complex inheritance).
PenetranceNCCD: high penetrance in homozygotes described in the clinical series. ECLE: variable penetrance and variable age of onset; complex inheritance. Hair length I and furnishing: complete penetrance as coat markers.
Codedakh
Turnaround time15 days
Price126,89 €

Incidence

Applicable breed: Vizsla. Reliable country-specific frequencies for the breeding population are not published systematically (limited data). ECLE is a well-recognised condition in the breed but with a complex genetic basis.

Breeder management

- Genotype breeding animals before mating; the panel covers four conditions/markers in a single sample\n- For NCCD (recessive): do not cross two carriers - 25% risk of affected homozygotes; carrier x clear is safe for offspring intended for breeding if tested\n- For ECLE: as it is a complex inheritance, the molecular test (if the laboratory includes it) does not predict risk deterministically; assess the family clinical history\n- For hair length I and furnishing: they guide coat prediction; they do not imply disease, but they inform the buyer\n- After a confirmed clinical case, do not repeat the parental cross and communicate the status to the buyer

Specialist notes

Verify the exact panel contracted. NCCD is suspected by cerebellar ataxia in puppies; the differential diagnosis includes other cerebellar abiotrophies and malformations. ECLE is diagnosed by skin biopsy (histopathology and immunofluorescence) and molecular test; the differential diagnosis includes other autoimmune and infectious dermatoses. Hair length I and furnishing do not predict disease.

References

1. Fenn J et al. 2016, SNX14 y nueva degeneración cortical cerebelosa en Vizsla (PMID 27566131)

Tests included in this pack (4)

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