Pug Pack: Pyruvate Kinase Deficiency (PK), Primary Lens Luxation (PLL), Necrotizing Meningoencephalitis (NME/PDE), Degenerative Myelopathy (DM exon 2)
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Panel genético multienfermedad para el Carlino (Pug) que reúne cuatro pruebas moleculares: deficiencia de piruvato quinasa (PK), luxación primaria de lente (PLL), meningoencefalitis necrotizante / enfermedad del perro pequeño (NME/PDE) y mielopatía degenerativa (DM exón 2). Cada condición tiene base molecular y herencia propia. El panel es complementario del seguimiento hemático, oftalmológico y neurológico en la selección reproductiva.
Diseases included in this pack
Necrotizing Meningoencephalitis (NME/PDE) (Multifactorial (non-monogenic): polygenic and immunogenetic predisposition linked to the DLA/MHC region (CFA12) and to other loci.)
An inflammatory brain disease specific to the Pug, formerly known as Pug dog encephalitis (PDE) and later renamed necrotizing meningoencephalitis (NME). It is an immune process, with lymphoplasmacytic infiltration, parenchymal necrosis and bilateral lesions predominantly in the brain. It produces progressive central…
Canine Degenerative Myelopathy exon 2 (All Breeds) (Autosomal recessive with age-dependent and incomplete penetrance)
Neurodegenerative disease of the spinal cord, the canine equivalent of human amyotrophic lateral sclerosis (ALS) due to SOD1 mutations. The classic variant (exon 2 of the SOD1 gene, described in 'all breeds') produces a dysfunctional superoxide dismutase 1 and degeneration of the long spinal tracts, with progressive…
Primary Lens Luxation (PLL) (Autosomal recessive (OMIA:000588-9615; Farias et al. 2010).)
Progressive weakening of the zonules of Zinn that causes displacement of the lens. It is a hereditary, non-inflammatory ocular disease, distinct from luxations secondary to cataract, uveitis, previous glaucoma or trauma. When the lens moves into the anterior chamber it can trigger a painful acute glaucoma and rapid…
PK Pyruvate Kinase Deficiency in Dogs (Autosomal recessive (OMIA:000844-9615).)
Molecular test for pyruvate kinase deficiency (PK Def), an autosomal recessive hereditary erythroenzymopathy caused by PK deficiency in the erythrocyte. Red blood cell half-life is shortened and it produces chronic regenerative hemolytic anemia, intermittent weakness, hepatosplenomegaly in the first year and, in adv…
Frequently asked questions
What does this pack include?
It includes 4 hereditary disease tests: Necrotizing Meningoencephalitis (NME/PDE), Canine Degenerative Myelopathy exon 2 (All Breeds), Primary Lens Luxation (PLL), PK Pyruvate Kinase Deficiency in Dogs. All are analysed in our laboratory.
What do the results mean?
The report shows the genotype and inheritance pattern of each variant. It is a breeding-decision tool: it guides which crosses to avoid, it does not guarantee the absence of disease.
How is the sample taken?
Buccal swab or 0.5–1 ml EDTA blood. The kit ships free to Spain, the EU and the UK.
