Labradoodle Pack: Progressive Retinal Atrophy (prcd-PRA), Progressive Retinal Atrophy (rcd4-PRA), Exercise-Induced Collapse (EIC), Skeletal Dysplasia 2 (Dwarfism) (SD2), Neonatal Encephalopathy with Seizures (NEWS), von Willebrand Disease Type 1 (vWD1), De

Panel genético multienfermedad para el Labradoodle (cruce Labrador × Caniche) que agrupa nueve pruebas moleculares: dos formas de atrofia progresiva de retina (prcd-PRA y rcd4-PRA), colapso inducido por el ejercicio (EIC), displasia esquelética 2/enanismo (SD2), encefalopatía neonatal con convulsiones (NEWS), enfermedad de von Willebrand tipo 1 (vWD1), mielopatía degenerativa (DM exón 2), miopatía centronuclear (CNM) y paraqueratosis nasal hereditaria (HNPK). El panel reúne variantes descritas tanto en el Labrador retriever como en el Caniche, lo que refleja el origen híbrido de la raza. La prueba molecular es complementaria del examen ocular, neuromuscular y hemostático en la selección reproductiva.

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Diseases included in this pack

Neonatal Encephalopathy (NEWS) (Autosomal recessive)

Neonatal encephalopathy with seizures, autosomal recessive, of the Standard Poodle. Affected puppies are small and weak at birth, suckle poorly, and if they survive the first week they develop ataxia, generalised tremor and severe tonic-clonic seizures between 4 and 6 weeks, refractory to treatment, with death or eu…

Hereditary Nasal Parakeratosis (HNPK) (Autosomal recessive (OMIA:001373-9615).)

Molecular test for hereditary nasal parakeratosis (HNPK), a monogenic autosomal recessive dermatosis of the Labrador retriever that produces crusts and fissures on the nasal planum from an early age. It affects the skin of the muzzle and compromises welfare through discomfort, fissuring and risk of secondary infecti…

Canine Degenerative Myelopathy exon 2 (All Breeds) (Autosomal recessive with age-dependent and incomplete penetrance)

Neurodegenerative disease of the spinal cord, the canine equivalent of human amyotrophic lateral sclerosis (ALS) due to SOD1 mutations. The classic variant (exon 2 of the SOD1 gene, described in 'all breeds') produces a dysfunctional superoxide dismutase 1 and degeneration of the long spinal tracts, with progressive…

von Willebrand Disease Type 1 (Autosomal dominant with incomplete penetrance (classic Doberman form, VWF c.7437G>A))

Von Willebrand disease (vWD) type 1 is an inherited coagulopathy caused by a quantitative deficiency of von Willebrand factor (vWF), a protein required for platelet adhesion to damaged endothelium. The result is a tendency to excessive bleeding, especially from mucous membranes (gums, nose, bladder, digestive tract)…

Canine rcd4-PRA (Autosomal recessive)

Progressive Retinal Atrophy type rcd4 (rcd4-PRA) is a form of progressive retinal degeneration described in several dog breeds. It involves the gradual loss of photoreceptors (cones and rods), with initial night blindness and progression towards marked visual loss. It is distinguished from other PRAs by its later on…

Canine Progressive Retinal Atrophy (prcd-PRA) (Autosomal recessive)

Inherited degeneration of the retinal photoreceptors. It begins by affecting the rods (night blindness, difficulty in low light) and progresses toward total vision loss in the medium to long term. It is the most common form of progressive retinal atrophy in dogs and is painless, so it is usually detected late, when…

Skeletal Dysplasia 2 (Dwarfism) (SD2) (Autosomal recessive with incomplete penetrance (OMIA:001772-9615).)

Mild form of disproportionate dwarfism in the Labrador Retriever with short limbs (mainly the forelimbs) and a body of normal length and width, with no ocular or auditory involvement. Height at the withers is reduced by around 6 cm compared with the standard, and the disease is not associated with significant second…

Exercise-Induced Collapse (EIC) (Autosomal recessive (OMIA:001466-9615).)

Exercise-Induced Collapse (EIC) is an inherited neuromuscular disease that mainly affects the Labrador Retriever and other retriever breeds. It is characterised by episodes of muscle weakness and collapse that occur during or immediately after intense exercise and subside within a few minutes, with the dog normal be…

Centronuclear Myopathy (CNM) Labradoodle (Autosomal recessive)

Centronuclear myopathy (CNM) of the Labrador retriever is a hereditary disease of skeletal muscle with autosomal recessive inheritance. It is characterised by weakness, hypotonia and progressive muscle atrophy appearing from the first month of life. The cause is an insertion of a SINE element in exon 2 of the HACD1…

Frequently asked questions

What does this pack include?

It includes 9 hereditary disease tests: Neonatal Encephalopathy (NEWS), Hereditary Nasal Parakeratosis (HNPK), Canine Degenerative Myelopathy exon 2 (All Breeds), von Willebrand Disease Type 1…. All are analysed in our laboratory.

What do the results mean?

The report shows the genotype and inheritance pattern of each variant. It is a breeding-decision tool: it guides which crosses to avoid, it does not guarantee the absence of disease.

How is the sample taken?

Buccal swab or 0.5–1 ml EDTA blood. The kit ships free to Spain, the EU and the UK.