Bull Terrier Pack: Laryngeal Paralysis (LP), Lethal Acrodermatitis (LAD), Primary Lens Luxation (PLL)

Panel genético para el Bull terrier que agrupa tres pruebas moleculares de enfermedades hereditarias descritas en la raza: parálisis laríngea hereditaria (LP), acrodermatitis letal (LAD) y luxación primaria de lente (PLL). Cada condición tiene base molecular distinta y patrón de herencia propio. El panel permite identificar portadores y planificar cruces minimizando la aparición de animales enfermos; no sustituye al examen ocular ni a la valoración clínica respiratoria.

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Diseases included in this pack

Lethal Acrodermatitis (LAD) (Bull Terrier and Miniature Bull Terrier) (Autosomal recessive. Affected homozygotes show the disease; heterozygotes are healthy carriers.)

Lethal acrodermatitis (LAD) is a severe genetic disease of the Bull Terrier and the Miniature Bull Terrier, with autosomal recessive inheritance, caused by a splicing defect in the MKLN1 gene. It presents with erosive and scaling skin lesions on the limbs and muzzle, diarrhoea, pneumonia, growth retardation and immu…

Primary Lens Luxation (PLL) (Autosomal recessive (OMIA:000588-9615; Farias et al. 2010).)

Progressive weakening of the zonules of Zinn that causes displacement of the lens. It is a hereditary, non-inflammatory ocular disease, distinct from luxations secondary to cataract, uveitis, previous glaucoma or trauma. When the lens moves into the anterior chamber it can trigger a painful acute glaucoma and rapid…

Laryngeal Paralysis (LP) Bull Terrier RAPGEF6 (Multifactorial (OMIA:002222-9615); recessive risk allele with incomplete penetrance)

Early-onset laryngeal paralysis in the Bull terrier and Miniature Bull terrier in which an insertion in the RAPGEF6 gene acts as a major risk factor. It is a multifactorial trait: the variant modulates risk but does not determine it, so homozygosity should be interpreted as increased risk and not as a diagnosis of d…

Frequently asked questions

What does this pack include?

It includes 3 hereditary disease tests: Lethal Acrodermatitis (LAD) (Bull Terrier and Miniature Bull Terrier), Primary Lens Luxation (PLL), Laryngeal Paralysis (LP) Bull Terrier RAPGEF6. All are analysed in our laboratory.

What do the results mean?

The report shows the genotype and inheritance pattern of each variant. It is a breeding-decision tool: it guides which crosses to avoid, it does not guarantee the absence of disease.

How is the sample taken?

Buccal swab or 0.5–1 ml EDTA blood. The kit ships free to Spain, the EU and the UK.