Molecular test for Basenji Fanconi syndrome, a hereditary renal tubulopathy that alters proximal tubular reabsorption of glucose, amino acids and other solutes. It affects the renal/urinary system and causes polyuria-polydipsia, glucosuria with normoglycemia and, in advanced stages, renal failure. The test reports clear/carrier/affected status.

Applicable breed: Basenji. The FAN1 deletion has been associated with the syndrome in the breed; carrier figures vary between populations and are not consolidated by country.

- Polyuria and polydipsia\n- Glucosuria with normal blood glucose\n- Weight loss despite preserved appetite\n- Aminoaciduria and tubular proteinuria\n- Metabolic acidosis and renal failure in advanced stages

Basenji Fanconi syndrome was described in the late 1970s as a model of renal tubular transport defect. Linkage studies in a large Basenji family located the causal variant in FAN1, and in 2024 a 317 bp deletion in exon 14 was published as the molecular cause of the disease, with a test available for the breed.

- Genotype breeding dogs before mating\n- Do not mate carrier×carrier (25% risk of affected homozygotes); carrier×clear produces 0% affected and 50% carriers\n- An affected animal should not be bred; a carrier can be mated to a clear dog without producing affected offspring\n- After a confirmed clinical case, do not repeat the parental mating and communicate the status to the buyer

Confirmation by urinalysis (glucosuria with normoglycemia) and renal biochemistry. Differentiate from diabetes mellitus and from other acquired or toxic renal tubulopathies. Symptomatic management: bicarbonate supplementation, acid-base balance control, hydration and monitoring of renal function.

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2. Bovee KC, et al. The Fanconi syndrome in Basenji dogs: a new model for renal transport defects. Science. 1978;201(4361):1129-1131. PMID: 684432
3. Yearley JH, et al. Survival time, lifespan, and quality of life in dogs with idiopathic Fanconi syndrome. J Am Vet Med Assoc. 2004;225(3):377-383. PMID: 15328712
4. Bax HA. [Inventory of Fanconi syndrome in Basenji dogs in The Netherlands]. Tijdschr Diergeneeskd. 2005;130(16):472-474. PMID: 16130757