White Swiss Shepherd Pack: MDR1 Defect (Ivermectin Hypersensitivity), Pituitary Dwarfism, Degenerative Myelopathy (DM exon 2)
133,98 € VAT incl.
Panel multienfermedad dirigido al pastor blanco suizo que agrupa las tres pruebas de sus componentes: defecto MDR-1 (ABCB1, hipersensibilidad a fármacos), enanismo hipofisario congénito (LHX3) y mielopatía degenerativa (DM, SOD1 exón 2). Cada prueba informa del estatus libre/portador/afecto para la variante correspondiente y permite planificar cruces. El panel no sustituye al seguimiento clínico: la sensibilidad MDR-1 exige precaución terapéutica de por vida y la DM es de penetrancia incompleta.
Diseases included in this pack
Pituitary Dwarfism (Pituitary Form) (Autosomal recessive)
Hereditary pituitary dwarfism of the German Shepherd and related breeds, caused by combined deficiency of pituitary hormones (GH, TSH, gonadal hormones) due to mutations in LHX3. Puppies are born normal but reduce their growth rate; they present reduced stature, persistent puppy coat with symmetrical alopecia of the…
Canine Degenerative Myelopathy exon 2 (All Breeds) (Autosomal recessive with age-dependent and incomplete penetrance)
Neurodegenerative disease of the spinal cord, the canine equivalent of human amyotrophic lateral sclerosis (ALS) due to SOD1 mutations. The classic variant (exon 2 of the SOD1 gene, described in 'all breeds') produces a dysfunctional superoxide dismutase 1 and degeneration of the long spinal tracts, with progressive…
Canine MDR1, Genetic Defect (Ivermectin and Other Drug Sensitivity) (Autosomal recessive with a dose effect (heterozygotes show intermediate sensitivity at high doses))
Loss-of-function mutation in the ABCB1 gene (formerly MDR1) that encodes P-glycoprotein, a drug efflux pump present in the blood-brain barrier. Without this pump, certain drugs (ivermectin and other endectocides, loperamide, some chemotherapeutic agents such as doxorubicin/vincristine and certain anaesthetics) accum…
Frequently asked questions
What does this pack include?
It includes 3 hereditary disease tests: Pituitary Dwarfism (Pituitary Form), Canine Degenerative Myelopathy exon 2 (All Breeds), Canine MDR1, Genetic Defect (Ivermectin and Other Drug Sensitivity). All are analysed in our laboratory.
What do the results mean?
The report shows the genotype and inheritance pattern of each variant. It is a breeding-decision tool: it guides which crosses to avoid, it does not guarantee the absence of disease.
How is the sample taken?
Buccal swab or 0.5–1 ml EDTA blood. The kit ships free to Spain, the EU and the UK.
