Tibetan Terrier Pack: Progressive Retinal Atrophy (PRA3), Progressive Retinal Atrophy (rcd4-PRA), Pituitary Dwarfism, Neuronal Ceroid Lipofuscinosis (NCL), Primary Lens Luxation (PLL), Degenerative Myelopathy (DM exon 2)

Panel multienfermedad para el Tibetan terrier que agrupa seis pruebas moleculares: atrofia progresiva de retina tipo 3 (PRA3), atrofia progresiva de retina rcd4 (rcd4-PRA), enanismo pituitario, lipofuscinosis neuronal ceroide (NCL), luxación primaria de lente (PLL) y mielopatía degenerativa (DM exón 2). Combina afecciones oculares, endocrinas, neurodegenerativas y neurológicas.

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Diseases included in this pack

Progressive Retinal Atrophy (PRA3) (Autosomal recessive)

Form of progressive retinal atrophy described in the Tibetan Spaniel and the Tibetan Terrier. It produces progressive degeneration of the retinal photoreceptors, first the rods and later the cones. Affected dogs lose night vision and, over time, day vision, progressing towards blindness. It does not cause pain but i…

Pituitary Dwarfism (Pituitary Form) (Autosomal recessive)

Hereditary pituitary dwarfism of the German Shepherd and related breeds, caused by combined deficiency of pituitary hormones (GH, TSH, gonadal hormones) due to mutations in LHX3. Puppies are born normal but reduce their growth rate; they present reduced stature, persistent puppy coat with symmetrical alopecia of the…

Canine Degenerative Myelopathy exon 2 (All Breeds) (Autosomal recessive with age-dependent and incomplete penetrance)

Neurodegenerative disease of the spinal cord, the canine equivalent of human amyotrophic lateral sclerosis (ALS) due to SOD1 mutations. The classic variant (exon 2 of the SOD1 gene, described in 'all breeds') produces a dysfunctional superoxide dismutase 1 and degeneration of the long spinal tracts, with progressive…

Neuronal Ceroid Lipofuscinosis 12 (NCL12) Tibetan Terrier (Autosomal recessive.)

Ceroid neuronal lipofuscinosis 12 (NCL12) of the Tibetan terrier is an adult-onset neurodegenerative disease included in the group of neuronal ceroid lipofuscinoses (Batten disease), characterised by intraneuronal accumulation of autofluorescent material and neuronal death. In the Tibetan terrier behavioural and vis…

Primary Lens Luxation (PLL) (Autosomal recessive (OMIA:000588-9615; Farias et al. 2010).)

Progressive weakening of the zonules of Zinn that causes displacement of the lens. It is a hereditary, non-inflammatory ocular disease, distinct from luxations secondary to cataract, uveitis, previous glaucoma or trauma. When the lens moves into the anterior chamber it can trigger a painful acute glaucoma and rapid…

Canine rcd4-PRA (Autosomal recessive)

Progressive Retinal Atrophy type rcd4 (rcd4-PRA) is a form of progressive retinal degeneration described in several dog breeds. It involves the gradual loss of photoreceptors (cones and rods), with initial night blindness and progression towards marked visual loss. It is distinguished from other PRAs by its later on…

Frequently asked questions

What does this pack include?

It includes 6 hereditary disease tests: Progressive Retinal Atrophy (PRA3), Pituitary Dwarfism (Pituitary Form), Canine Degenerative Myelopathy exon 2 (All Breeds), Neuronal Ceroid Lipofuscinosis 12 (NCL12) Tibetan Terrier…. All are analysed in our laboratory.

What do the results mean?

The report shows the genotype and inheritance pattern of each variant. It is a breeding-decision tool: it guides which crosses to avoid, it does not guarantee the absence of disease.

How is the sample taken?

Buccal swab or 0.5–1 ml EDTA blood. The kit ships free to Spain, the EU and the UK.