Shiba Inu Pack: GM1-Gangliosidosis (GM1), GM2-Gangliosidosis (GM2), A-locus, E-locus
153,54 € VAT incl.
Panel multienfermedad para el Shiba inu que agrupa cuatro pruebas moleculares: gangliosidosis GM1 (GLB1), gangliosidosis GM2 (HEXB) y dos loci de capa —A-locus (ASIP) y E-locus (MC1R, alelo e1)—. Combina dos enfermedades neurometabólicas graves, ambas autosómicas recesivas y letales en homocigosis, con dos marcadores de capa de utilidad para la cría.
Diseases included in this pack
Gangliosidosis (GM1) (Autosomal recessive)
Lysosomal storage disease due to acid beta-galactosidase deficiency, which causes accumulation of GM1 gangliosides in the central nervous system and in various organs. It produces a progressive neurodegeneration of early onset with ataxia, cerebellar signs and weakness, and is lethal in the first months/years of lif…
Gangliosidosis (GM2) (Autosomal recessive (OMIA:001462-9615 and OMIA:001461-9615).)
Lysosomal storage disorder due to beta-hexosaminidase deficiency that causes accumulation of GM2 gangliosides in the nervous system. The most frequent form in the dog is variant 0 (Sandhoff), due to variants in HEXB that affect hexosaminidase A and B; in the Japanese Chin a Tay-Sachs-like form (type I / variant B) d…
locus e1, K-locus (e1 recessive; K^B dominant)
Coat colour genetic test that determines the genotype of the Extension locus (E, MC1R gene) for the e1 allele (recessive red) and, depending on the panel, the K locus (Dominant Black, CBD103 gene) in the Poodle. The e1 allele in homozygosity (e1/e1) blocks eumelanin production and gives a red/apricot coat, character…
Canine A-Locus (ASIP) Shiba Inu (It is not a simple recessive trait: it depends on the combination of ASIP VP/HCP promoter haplotypes. Red sesame is associated with the heterozygous diplotype VP2-HCP1/VP2-HCP3 (haplotypes A^ys and a^t/BB1); darker sesame, with the a^w/a^t genotype.)
The canine A locus (ASIP) regulates the distribution of eumelanin (black/brown) and pheomelanin (yellow/red) in the coat. It is not a simple recessive system: it is modulated by two independent promoters (the ventral promoter, VP, and the hair-cycle-specific promoter, HCP), whose combined activity generates the patt…
Frequently asked questions
What does this pack include?
It includes 4 hereditary disease tests: Gangliosidosis (GM1), Gangliosidosis (GM2), locus e1, K-locus, Canine A-Locus (ASIP) Shiba Inu. All are analysed in our laboratory.
What do the results mean?
The report shows the genotype and inheritance pattern of each variant. It is a breeding-decision tool: it guides which crosses to avoid, it does not guarantee the absence of disease.
How is the sample taken?
Buccal swab or 0.5–1 ml EDTA blood. The kit ships free to Spain, the EU and the UK.
