Russell Terrier Pack 1: Juvenile Brain Disease (JBD), Late-Onset Ataxia (LOA), Spinocerebellar Ataxia (SCA)
133,98 € VAT incl.
Panel genético del Russell terrier (y terrier del grupo Russell, incluido Parson Russell terrier) que agrupa tres enfermedades neurodegenerativas hereditarias recesivas distintas: la enfermedad cerebral juvenil (JBD), la ataxia de aparición tardía (LOA) y la ataxia espinocerebelosa con miokimia y/o crisis (SCA/SAMS). JBD (PITRM1) y SCA/SAMS (KCNJ10) tienen base molecular consolidada; la asociación de LOA con CAPN1 está descrita pero es discutida. Las pruebas genéticas son específicas para cada variante.
Diseases included in this pack
Juvenile Brain Disease (JBD) (Autosomal recessive)
Juvenile mitochondrial encephalopathy of the Parson Russell Terrier, with epileptic seizures starting between 6 and 12 weeks of age, ataxia and rapid, irreversible neurological deterioration. It is inherited in an autosomal recessive manner and is associated with an in-frame deletion in the PITRM1 gene, which encode…
Late-Onset Ataxia (LOA) (Autosomal recessive)
Hereditary late-onset cerebellar ataxia described in the Jack Russell terrier and the Parson Russell terrier. It causes progressive degeneration of the Purkinje cells of the cerebellar cortex, affecting motor coordination. Affected dogs maintain mental status and sensory function, but progressively lose the ability…
Canine Cerebellar Ataxia (Autosomal recessive)
Hereditary cerebellar ataxia of the Russell group of terriers and the Fox terrier, caused by a mutation in KCNJ10 (potassium channel Kir4.1). It presents with progressive ataxia, with or without myokymia (fasciculations and muscle rippling) and with or without seizures, and is therefore also known as spinocerebellar…
Frequently asked questions
What does this pack include?
It includes 3 hereditary disease tests: Juvenile Brain Disease (JBD), Late-Onset Ataxia (LOA), Canine Cerebellar Ataxia. All are analysed in our laboratory.
What do the results mean?
The report shows the genotype and inheritance pattern of each variant. It is a breeding-decision tool: it guides which crosses to avoid, it does not guarantee the absence of disease.
How is the sample taken?
Buccal swab or 0.5–1 ml EDTA blood. The kit ships free to Spain, the EU and the UK.
