Irish Setter (Red and White) Pack: Progressive Retinal Atrophy (rcd1-PRA), Progressive Retinal Atrophy (rcd4-PRA), Leukocyte Adhesion Deficiency (CLAD), Globoid Cell Leukodystrophy (Krabbe)

Panel multienfermedad para el Setter irlandés (rojo y blanco) que agrupa cuatro pruebas moleculares: atrofia progresiva de retina rcd1 (rcd1-PRA), atrofia progresiva de retina rcd4 (rcd4-PRA), deficiencia de adhesión leucocitaria canina (CLAD) y leucodistrofia de células globoides (enfermedad de Krabbe). Combina afecciones oculares, inmunológicas y neurodegenerativas.

View full details →

Diseases included in this pack

Globoid Cell Leukodystrophy (Autosomal recessive)

Lysosomal storage disorder due to galactocerebrosidase (GALC) deficiency that accumulates psychosine and causes demyelination of the central and peripheral nervous system. In dogs, distinct GALC mutations are recognised in the Cairn Terrier and West Highland White Terrier (shared) and in the Irish Setter (independen…

rcd1-PRA (Autosomal recessive)

Progressive retinal atrophy due to rod-cone dystrophy type 1 (rcd1) in the Irish Setter and the Irish Red and White Setter. Early and progressive degeneration of retinal photoreceptors leading to blindness. It was one of the first forms of canine PRA characterised at the molecular level.

Leukocyte Adhesion Deficiency (CLAD) (Autosomal recessive)

Hereditary disease caused by a defect in beta-2 integrin (CD18) that prevents neutrophil adhesion and migration to tissues. Affected dogs show marked leukocytosis with neutrophils that do not leave the bloodstream, giving rise to severe recurrent bacterial infections and failure to thrive. Without treatment it is us…

Canine rcd4-PRA (Autosomal recessive)

Progressive Retinal Atrophy type rcd4 (rcd4-PRA) is a form of progressive retinal degeneration described in several dog breeds. It involves the gradual loss of photoreceptors (cones and rods), with initial night blindness and progression towards marked visual loss. It is distinguished from other PRAs by its later on…

Frequently asked questions

What does this pack include?

It includes 4 hereditary disease tests: Globoid Cell Leukodystrophy, rcd1-PRA, Leukocyte Adhesion Deficiency (CLAD), Canine rcd4-PRA. All are analysed in our laboratory.

What do the results mean?

The report shows the genotype and inheritance pattern of each variant. It is a breeding-decision tool: it guides which crosses to avoid, it does not guarantee the absence of disease.

How is the sample taken?

Buccal swab or 0.5–1 ml EDTA blood. The kit ships free to Spain, the EU and the UK.