German Shepherd and Czechoslovakian Wolfdog Pack: Pituitary Dwarfism, Hyperuricosuria (HUU/SLC), Degenerative Myelopathy (DM exon 2), Long Hair/Short Hair, Ivermectin Sensitivity (MDR1)

Panel genético multienfermedad para el Pastor alemán y el Perro lobo checoslovaco que agrupa cinco pruebas moleculares: enanismo pituitario (LHX3), hiperuricosuria (SLC2A9), mielopatía degenerativa (SOD1 exón 2), sensibilidad a ivermectina (MDR1/ABCB1) y longitud del pelo (FGF5). Combina condiciones endocrinas, urológicas, neurológicas, farmacogenéticas y un marcador de capa. El panel es complementario del examen clínico y neurológico en la selección reproductiva.

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Diseases included in this pack

Hyperuricosuria (SLC) (Autosomal recessive)

Hyperuricosuria is a defect of renal uric acid transport caused by a variant of the SLC2A9 gene, historically described as G616T (p.Cys188Phe) and also noted as Cys181Phe depending on the reference transcript. It increases urinary urate excretion and the risk of urate uroliths. The Dalmatian is the paradigmatic breed.

Pituitary Dwarfism (Pituitary Form) (Autosomal recessive)

Hereditary pituitary dwarfism of the German Shepherd and related breeds, caused by combined deficiency of pituitary hormones (GH, TSH, gonadal hormones) due to mutations in LHX3. Puppies are born normal but reduce their growth rate; they present reduced stature, persistent puppy coat with symmetrical alopecia of the…

Canine Degenerative Myelopathy exon 2 (All Breeds) (Autosomal recessive with age-dependent and incomplete penetrance)

Neurodegenerative disease of the spinal cord, the canine equivalent of human amyotrophic lateral sclerosis (ALS) due to SOD1 mutations. The classic variant (exon 2 of the SOD1 gene, described in 'all breeds') produces a dysfunctional superoxide dismutase 1 and degeneration of the long spinal tracts, with progressive…

Canine MDR1, Genetic Defect (Ivermectin and Other Drug Sensitivity) (Autosomal recessive with a dose effect (heterozygotes show intermediate sensitivity at high doses))

Loss-of-function mutation in the ABCB1 gene (formerly MDR1) that encodes P-glycoprotein, a drug efflux pump present in the blood-brain barrier. Without this pump, certain drugs (ivermectin and other endectocides, loperamide, some chemotherapeutic agents such as doxorubicin/vincristine and certain anaesthetics) accum…

Long Hair/Short Hair, Ivermectin Sensitivity (MDR1) (Mixed: long coat (FGF5) — autosomal recessive; MDR-1 defect (ABCB1) — incomplete dominant (dose-dependent).)

Panel aimed at the German Shepherd and the Czechoslovakian Wolfdog that combines tests of the FGF5 gene for the coat-length phenotype (long coat/short coat) with the MDR-1 defect test (hypersensitivity to ivermectin and other drugs that are P-glycoprotein substrates). The first block reports the genetic status for c…

Frequently asked questions

What does this pack include?

It includes 5 hereditary disease tests: Hyperuricosuria (SLC), Pituitary Dwarfism (Pituitary Form), Canine Degenerative Myelopathy exon 2 (All Breeds), Canine MDR1, Genetic Defect (Ivermectin and Other Drug Sensitivity)…. All are analysed in our laboratory.

What do the results mean?

The report shows the genotype and inheritance pattern of each variant. It is a breeding-decision tool: it guides which crosses to avoid, it does not guarantee the absence of disease.

How is the sample taken?

Buccal swab or 0.5–1 ml EDTA blood. The kit ships free to Spain, the EU and the UK.