Chinese Crested Pack: Progressive Retinal Atrophy (prcd-PRA), Progressive Retinal Atrophy (rcd3-PRA), Canine Multiple Systemic Degeneration (CMSD), Neuronal Ceroid Lipofuscinosis (NCL), Primary Lens Luxation (PLL), Degenerative Myelopathy (DM exon 2)
153,54 € VAT incl.
Panel genético multienfermedad para el Perro crestado chino que agrupa seis pruebas moleculares de afecciones hereditarias descritas en la raza: dos formas de atrofia progresiva de retina (prcd-PRA y rcd3-PRA), degeneración sistémica múltiple canina (CMSD), lipofuscinosis neuronal ceroide (NCL), luxación primaria de lente (PLL) y mielopatía degenerativa (DM exón 2). Cada prueba informa del estatus libre/portador/afecto para la variante correspondiente y permite planificar cruces evitando animales enfermos. El panel no sustituye al examen ocular ni al seguimiento neurológico: varias afecciones son tardías o de penetrancia variable, y la prueba molecular es solo una pieza del manejo reproductivo.
Diseases included in this pack
Canine Degenerative Myelopathy exon 2 (All Breeds) (Autosomal recessive with age-dependent and incomplete penetrance)
Neurodegenerative disease of the spinal cord, the canine equivalent of human amyotrophic lateral sclerosis (ALS) due to SOD1 mutations. The classic variant (exon 2 of the SOD1 gene, described in 'all breeds') produces a dysfunctional superoxide dismutase 1 and degeneration of the long spinal tracts, with progressive…
Multiple System Degeneration (Chinese Crested) (Autosomal recessive. Only affected homozygotes show signs; heterozygous carriers are clinically normal.)
Inherited, progressive neurodegenerative disorder of the Chinese Crested dog, with degeneration of the cerebellum, caudate nucleus and substantia nigra. It appears in puppies or young dogs and progresses to inability to remain standing and euthanasia. The cause is loss of function of the SERAC1 gene. It is a test co…
Primary Lens Luxation (PLL) (Autosomal recessive (OMIA:000588-9615; Farias et al. 2010).)
Progressive weakening of the zonules of Zinn that causes displacement of the lens. It is a hereditary, non-inflammatory ocular disease, distinct from luxations secondary to cataract, uveitis, previous glaucoma or trauma. When the lens moves into the anterior chamber it can trigger a painful acute glaucoma and rapid…
Neuronal Ceroid Lipofuscinosis 7 (NCL7) Chinese Crested (Autosomal recessive. Homozygotes develop the disease and heterozygotes are clinically normal carriers.)
Neuronal ceroid lipofuscinosis 7 (NCL7 or CLN7) is a neurodegenerative lysosomal storage disease with autosomal recessive inheritance caused by variants in the MFSD8 (CLN7) gene. It was first described in the Chinese Crested and the same variant has been documented in the Chihuahua. It produces progressive neurologi…
Canine Progressive Retinal Atrophy (prcd-PRA) (Autosomal recessive)
Inherited degeneration of the retinal photoreceptors. It begins by affecting the rods (night blindness, difficulty in low light) and progresses toward total vision loss in the medium to long term. It is the most common form of progressive retinal atrophy in dogs and is painless, so it is usually detected late, when…
rcd3-PRA (Autosomal recessive.)
Progressive retinal atrophy due to rod-cone dysplasia type 3 (rcd3), caused by a mutation in the PDE6A gene (alpha subunit of rod cGMP phosphodiesterase). Progressive degeneration of photoreceptors leading to blindness. The variant was first described in the Cardigan Welsh Corgi and the same variant has since been d…
Frequently asked questions
What does this pack include?
It includes 6 hereditary disease tests: Canine Degenerative Myelopathy exon 2 (All Breeds), Multiple System Degeneration (Chinese Crested), Primary Lens Luxation (PLL), Neuronal Ceroid Lipofuscinosis 7 (NCL7) Chinese Crested…. All are analysed in our laboratory.
What do the results mean?
The report shows the genotype and inheritance pattern of each variant. It is a breeding-decision tool: it guides which crosses to avoid, it does not guarantee the absence of disease.
How is the sample taken?
Buccal swab or 0.5–1 ml EDTA blood. The kit ships free to Spain, the EU and the UK.
