Test Detail
Bas-PRA1 - Basenji
Ocular · Dog
A form of progressive retinal atrophy specific to the Basenji, known as Bas-PRA1. It causes progressive degeneration of photoreceptors with gradual vision loss, first at night and then during the day. It is incurable and does not cause pain, but progresses to blindness.
Incidence
Specific to the Basenji, with adult onset. There are no systematically published carrier frequencies; the breed is few in number.
Breeder management
- Test breeding animals before mating\n- Do not mate two carriers\n- A carrier may be mated to a clear animal; test offspring intended for breeding\n- Preserve genetic diversity given the small population of the breed
Specialist notes
Differential diagnosis from other PRAs (including PRCD) and acquired retinopathies. Adult onset. There is no curative treatment. Tibetan Spaniel PRA is NOT caused by SAG (it is FAM161A), so it should not be equated with this.
References
Goldstein O et al. 2013. A non-stop S-antigen gene mutation is associated with late onset hereditary retinal degeneration in dogs. Mol Vis. PMID: 24019744; Downs LM et al. 2014. An Intronic SINE insertion in FAM161A that causes exon-skipping is associated with progressive retinal atrophy in Tibetan Spaniels and Tibetan Terriers. PLoS One. PMID: 24705771; OMIA:001876-9615